The role of osteopontin in the development of albuminuria
J Lorenzen, R Shah, A Biser, SA Staicu… - Journal of the …, 2008 - journals.lww.com
Several gene array studies have suggested that osteopontin (Opn) expression strongly
correlates with albuminuria and glomerular disease. Urinary Opn concentration and kidney
Opn immunoreactivity were found to be increased in patients with steroid-sensitive nephrotic
syndrome. In addition, renal Opn mRNA was increased in the Ins2 Akita mouse model of
type 1 diabetic nephropathy, in the LPS-induced albuminuria model, and in glomeruli of
puromycin aminonucleotide–induced nephrotic rats. Opn knockout mice did not develop …
correlates with albuminuria and glomerular disease. Urinary Opn concentration and kidney
Opn immunoreactivity were found to be increased in patients with steroid-sensitive nephrotic
syndrome. In addition, renal Opn mRNA was increased in the Ins2 Akita mouse model of
type 1 diabetic nephropathy, in the LPS-induced albuminuria model, and in glomeruli of
puromycin aminonucleotide–induced nephrotic rats. Opn knockout mice did not develop …