Blinded by the light
SG Jacobson, RR McInnes - Nature genetics, 2002 - nature.com
Nature genetics, 2002•nature.com
Excessive exposure to visible light damages the vertebrate retina. New work demonstrates
that two different pathways, a bright-light pathway and a low-light dependent pathway,
mediate light-induced retinal death. Although both pathways are initiated by excessive
activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is
AP-1-dependent and only the low-light pathway is dependent on phototransduction.
that two different pathways, a bright-light pathway and a low-light dependent pathway,
mediate light-induced retinal death. Although both pathways are initiated by excessive
activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is
AP-1-dependent and only the low-light pathway is dependent on phototransduction.
Excessive exposure to visible light damages the vertebrate retina. New work demonstrates that two different pathways, a bright-light pathway and a low-light dependent pathway, mediate light-induced retinal death. Although both pathways are initiated by excessive activation of the photopigment rhodopsin, they differ in that only the bright-light pathway is AP-1-dependent and only the low-light pathway is dependent on phototransduction.
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