G protein-coupled receptor kinases, β-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution
M Grange-Midroit, JA Garcı́a-Sevilla… - Molecular brain …, 2002 - Elsevier
G protein-coupled receptor kinases (GRKs) and β-arrestin-2 play a crucial role in the
regulation of neurotransmitter receptors in brain. In this study, GRK2, GRK6, β-arrestin-2 and
associated regulatory proteins (Gβ proteins and protein phosphatase (PP)-2A) were
quantitated in human brains (immunodensity with specific antibodies) to assess for
postmortem changes (pattern of protein degradation) and to investigate the effect of aging
on these regulatory proteins as well as their subcellular distribution (cytosol and membrane …
regulation of neurotransmitter receptors in brain. In this study, GRK2, GRK6, β-arrestin-2 and
associated regulatory proteins (Gβ proteins and protein phosphatase (PP)-2A) were
quantitated in human brains (immunodensity with specific antibodies) to assess for
postmortem changes (pattern of protein degradation) and to investigate the effect of aging
on these regulatory proteins as well as their subcellular distribution (cytosol and membrane …