[HTML][HTML] Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat
LF Ferrari, O Bogen, C Chu, JD Levine - The journal of pain, 2013 - Elsevier
Chronic pain is extremely difficult to manage, in part due to lack of progress in reversing the
underlying pathophysiology. Since translation of messenger ribonucleic acids (mRNAs) in
the peripheral terminal of the nociceptor plays a role in the transition from acute to chronic
pain, we tested the hypothesis that transient inhibition of translation in the peripheral
terminal of the nociceptor could reverse hyperalgesic priming, a model of transition from
acute to chronic pain. We report that injection of translation inhibitors rapamycin and …
underlying pathophysiology. Since translation of messenger ribonucleic acids (mRNAs) in
the peripheral terminal of the nociceptor plays a role in the transition from acute to chronic
pain, we tested the hypothesis that transient inhibition of translation in the peripheral
terminal of the nociceptor could reverse hyperalgesic priming, a model of transition from
acute to chronic pain. We report that injection of translation inhibitors rapamycin and …