Hyperalgesic priming in the rat demonstrates marked sexual dimorphism
EK Joseph, CA Parada, JD Levine - Pain, 2003 - Elsevier
In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein
kinase C epsilon (PKCε) agonist (ψεRACK) produces prolongation of the hyperalgesia
induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to
as hyperalgesic priming. Since many chronic inflammatory conditions are sexually
dimorphic, we tested the hypothesis that hyperalgesic priming is sexually dimorphic. Prior
injection of CAR or ψεRACK produced a prolongation of the hyperalgesia induced by a …
kinase C epsilon (PKCε) agonist (ψεRACK) produces prolongation of the hyperalgesia
induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to
as hyperalgesic priming. Since many chronic inflammatory conditions are sexually
dimorphic, we tested the hypothesis that hyperalgesic priming is sexually dimorphic. Prior
injection of CAR or ψεRACK produced a prolongation of the hyperalgesia induced by a …