Research on the role of axonal protein synthesis in the regulation of nociceptive
mechanisms has grown significantly over the past four years. Recent advances include
evidence that local translation of mRNA can occur in adult primary afferents under the
control of the mammalian target of rapamycin (mTOR) and the extracellular signal-regulated
kinase (ERK) signaling pathways. Studies investigating the effect of mTOR and ERK
pathway inhibitors in a number of pain models suggest that these signaling pathways may …