Silibinin protects mice from T cell-dependent liver injury☆

J Schümann, J Prockl, AK Kiemer, AM Vollmar… - Journal of …, 2003 - Elsevier
Background/Aims: Silibinin is the major pharmacologically active compound of the Silybum
marianum fruit extract silymarin. Its well-known hepatoprotective activities are mostly
explained by antioxidative properties, inhibition of phosphatidylcholine synthesis or
stimulation of hepatic RNA and protein synthesis. Here, we characterized the
hepatoprotective potential of silibinin as an immune-response modifier in T cell-dependent
hepatitis in vivo. Methods: Silibinin was tested in the mouse model of concanavalin A (ConA) …