[HTML][HTML] The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-κB for synergistic transcriptional activation of the CXC ligand 9/monokine …
M Hiroi, Y Ohmori - Journal of Biological Chemistry, 2003 - ASBMB
Signal transducers and activators of transcription 1 (STAT1) and NF-κB cooperatively
regulate the expression of many inflammatory genes. In the present study, we demonstrate
that the transcriptional coactivator CREB-binding protein (CBP) mediated the STAT1/NF-κB
synergy for transcription of the gene for CXC ligand 9 (CXCL9), an interferon-γ (IFN-γ)-
inducible chemokine. Reporter gene analysis showed that expression of CBP potentiated
IFN-γ and tumor necrosis factor (TNFα)-induced promoter activity and that the CBP-mediated …
regulate the expression of many inflammatory genes. In the present study, we demonstrate
that the transcriptional coactivator CREB-binding protein (CBP) mediated the STAT1/NF-κB
synergy for transcription of the gene for CXC ligand 9 (CXCL9), an interferon-γ (IFN-γ)-
inducible chemokine. Reporter gene analysis showed that expression of CBP potentiated
IFN-γ and tumor necrosis factor (TNFα)-induced promoter activity and that the CBP-mediated …