Vagal control of mucociliary clearance in murine lungs: a study in a chronic preparation
AR Bhashyam, PJ Mogayzel Jr, JC Cleary… - Autonomic …, 2010 - Elsevier
We conducted several experiments that focused on the effect of vagal control on mucociliary
clearance (MCC) in murine lungs. We hypothesized that loss of vagal control by chronic
denervation (ie vagotomy) would reduce both basal MCC and the increase in MCC typically
observed upon stimulation of capsaicin sensitive C-fibers. Vagotomy was performed on the
right side of C57BL/6 mice and MCC was measured 5days later. Mucociliary clearance was
measured by gamma scintigraphy after oropharyngeal aspiration of the radioisotope …
clearance (MCC) in murine lungs. We hypothesized that loss of vagal control by chronic
denervation (ie vagotomy) would reduce both basal MCC and the increase in MCC typically
observed upon stimulation of capsaicin sensitive C-fibers. Vagotomy was performed on the
right side of C57BL/6 mice and MCC was measured 5days later. Mucociliary clearance was
measured by gamma scintigraphy after oropharyngeal aspiration of the radioisotope …