Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis
B Zhang, JS Tzartos, M Belimezi, S Ragheb… - Archives of …, 2012 - jamanetwork.com
Objectives To determine whether patients with myasthenia gravis (MG) have serum
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is
essential for neuromuscular junction formation, and to establish whether such antibodies
contribute to MG pathogenesis. Design Serum samples from patients with MG with known
status of serum antibodies to the acetylcholine receptor (AChR) and muscle-specific kinase
(MuSK) and serum samples from control subjects (healthy individuals and individuals with …
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is
essential for neuromuscular junction formation, and to establish whether such antibodies
contribute to MG pathogenesis. Design Serum samples from patients with MG with known
status of serum antibodies to the acetylcholine receptor (AChR) and muscle-specific kinase
(MuSK) and serum samples from control subjects (healthy individuals and individuals with …