Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy
GJ van der Bij, M Bögels, MA Otten, SJ Oosterling… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Development of liver metastases is a frequent complication in
patients with colorectal cancer (CRC), even after successful resection of the primary tumor.
As such, post-operative adjuvant therapies that aim to eliminate residual disease after
surgery may improve patient outcome. METHODS: We used a colon carcinoma liver
metastases model, in which CC531s colon carcinoma cells are injected into the portal
circulation by a surgical procedure. As injected tumor cells are arrested in the liver, this …
patients with colorectal cancer (CRC), even after successful resection of the primary tumor.
As such, post-operative adjuvant therapies that aim to eliminate residual disease after
surgery may improve patient outcome. METHODS: We used a colon carcinoma liver
metastases model, in which CC531s colon carcinoma cells are injected into the portal
circulation by a surgical procedure. As injected tumor cells are arrested in the liver, this …