[HTML][HTML] Gα12/13-and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor …
M Nishida, S Tanabe, Y Maruyama, S Mangmool… - Journal of Biological …, 2005 - ASBMB
In the present study, we examined signal transduction mechanism of reactive oxygen
species (ROS) production and the role of ROS in angiotensin II-induced activation of
mitogen-activated protein kinases (MAPKs) in rat neonatal cardiomyocytes. Among three
MAPKs, c-Jun NH 2-terminal kinase (JNK) and p38 MAPK required ROS production for
activation, as an NADPH oxidase inhibitor, diphenyleneiodonium, inhibited the activation.
The angiotensin II-induced activation of JNK and p38 MAPK was also inhibited by the …
species (ROS) production and the role of ROS in angiotensin II-induced activation of
mitogen-activated protein kinases (MAPKs) in rat neonatal cardiomyocytes. Among three
MAPKs, c-Jun NH 2-terminal kinase (JNK) and p38 MAPK required ROS production for
activation, as an NADPH oxidase inhibitor, diphenyleneiodonium, inhibited the activation.
The angiotensin II-induced activation of JNK and p38 MAPK was also inhibited by the …