The neuropilin-1 (np1) and neuropilin-2 (np2) receptors function as receptors for the axon
guidance factors belonging to the class-3 semaphorin subfamily. In addition, both
neuropilins are able to bind to certain heparin-binding splice forms of vascular endothelial
growth factor (VEGF), indicating that both neuropilins have roles in the cardiovascular
system as well. Gene targeting experiments indicate that np1 does indeed function as an
important modulator of VEGF function during vasculogenesis and angiogenesis, but the role …