[HTML][HTML] Oxidants positively or negatively regulate nuclear factor κB in a context-dependent manner
N Loukili, N Rosenblatt-Velin, J Rolli, S Levrand… - Journal of Biological …, 2010 - ASBMB
Redox-based mechanisms play critical roles in the regulation of multiple cellular functions.
NF-κB, a master regulator of inflammation, is an inducible transcription factor generally
considered to be redox-sensitive, but the modes of interactions between oxidant stress and
NF-κB are incompletely defined. Here, we show that oxidants can either amplify or suppress
NF-κB activation in vitro by interfering both with positive and negative signals in the NF-κB
pathway. NF-κB activation was evaluated in lung A549 epithelial cells stimulated with tumor …
NF-κB, a master regulator of inflammation, is an inducible transcription factor generally
considered to be redox-sensitive, but the modes of interactions between oxidant stress and
NF-κB are incompletely defined. Here, we show that oxidants can either amplify or suppress
NF-κB activation in vitro by interfering both with positive and negative signals in the NF-κB
pathway. NF-κB activation was evaluated in lung A549 epithelial cells stimulated with tumor …