[HTML][HTML] Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling
M Jain, S Rivera, EA Monclus, L Synenki, A Zirk… - Journal of Biological …, 2013 - ASBMB
TGF-β signaling is required for normal tissue repair; however, excessive TGF-β signaling
can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-
β binds to cell-surface receptors, resulting in the phosphorylation of the Smad family of
transcription factors to initiate gene expression. TGF-β also initiates Smad-independent
pathways, which augment gene expression. Here, we report that mitochondrial reactive
oxygen species (ROS) generated at complex III are required for TGF-β-induced gene …
can lead to robust profibrotic gene expression in fibroblasts, resulting in tissue fibrosis. TGF-
β binds to cell-surface receptors, resulting in the phosphorylation of the Smad family of
transcription factors to initiate gene expression. TGF-β also initiates Smad-independent
pathways, which augment gene expression. Here, we report that mitochondrial reactive
oxygen species (ROS) generated at complex III are required for TGF-β-induced gene …