Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy
X Tan, Y Li, Y Liu - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Deficiency in vitamin D and its active metabolites is a pathologic feature of chronic kidney
diseases. Despite that tubular epithelial cells are the major sites of active vitamin D
synthesis, little is known about the role of vitamin D in maintaining the structural and
functional integrity of tubular epithelium. This study investigated the effects of paricalcitol (19-
nor-1, 25-hydroxy-vitamin D 2), a synthetic vitamin D analogue, on obstructive nephropathy,
a model that is characterized by predominant tubulointerstitial lesions. Compared with …
diseases. Despite that tubular epithelial cells are the major sites of active vitamin D
synthesis, little is known about the role of vitamin D in maintaining the structural and
functional integrity of tubular epithelium. This study investigated the effects of paricalcitol (19-
nor-1, 25-hydroxy-vitamin D 2), a synthetic vitamin D analogue, on obstructive nephropathy,
a model that is characterized by predominant tubulointerstitial lesions. Compared with …