The role of Smad3 in mediating mouse hepatic stellate cell activation
B Schnabl, YO Kweon, JP Frederick, XF Wang… - Hepatology, 2001 - journals.lww.com
Transforming growth factor β (TGF–β) is the most potent profibrogenic mediator in liver
fibrosis. Although Smad proteins have been identified as intracellular mediators in the TGF–
β signaling pathway, the function of individual Smad proteins remains poorly understood.
The aim of this study was to explore the contribution of Smad3 in mediating TGF–β
responses in a model of acute liver injury in vivo and in culture–activated hepatic stellate
cells (HSCs). Wild–type, Smad3 heterozygous or Smad3 homozygous knockout mice were …
fibrosis. Although Smad proteins have been identified as intracellular mediators in the TGF–
β signaling pathway, the function of individual Smad proteins remains poorly understood.
The aim of this study was to explore the contribution of Smad3 in mediating TGF–β
responses in a model of acute liver injury in vivo and in culture–activated hepatic stellate
cells (HSCs). Wild–type, Smad3 heterozygous or Smad3 homozygous knockout mice were …