[PDF][PDF] Arrestin development: emerging roles for β-arrestins in developmental signaling pathways

JJ Kovacs, MR Hara, CL Davenport, J Kim… - Developmental cell, 2009 - cell.com
JJ Kovacs, MR Hara, CL Davenport, J Kim, RJ Lefkowitz
Developmental cell, 2009cell.com
Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization
and endocytosis. However, it is now clear that they scaffold many intracellular signaling
networks to modulate the strength and duration of signaling by diverse types of receptors—
including those relevant to the Hedgehog, Wnt, Notch, and TGFβ pathways—and
downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of
arrestins in many discrete developmental signaling events suggests an indispensable role …
Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors—including those relevant to the Hedgehog, Wnt, Notch, and TGFβ pathways—and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds.
cell.com