[PDF][PDF] Genes that distinguish physiological and pathological angiogenesis

S Seaman, J Stevens, MY Yang, D Logsdon… - Cancer cell, 2007 - cell.com
S Seaman, J Stevens, MY Yang, D Logsdon, C Graff-Cherry, BS Croix
Cancer cell, 2007cell.com
To unravel the normal vasculature transcriptome and determine how it is altered by
neighboring malignant cells, we compared gene expression patterns of endothelial cells
derived from the blood vessels of eight normal resting tissues, five tumors, and regenerating
liver. Organ-specific endothelial genes were readily identified, including 27 from brain. We
also identified 25 transcripts overexpressed in tumor versus normal endothelium, including
13 that were not found in the angiogenic endothelium of regenerating liver. Most of the …
Summary
To unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the blood vessels of eight normal resting tissues, five tumors, and regenerating liver. Organ-specific endothelial genes were readily identified, including 27 from brain. We also identified 25 transcripts overexpressed in tumor versus normal endothelium, including 13 that were not found in the angiogenic endothelium of regenerating liver. Most of the shared angiogenesis genes have expected roles in cell-cycle control, but those specific for tumor endothelium were primarily cell surface molecules of uncertain function. These studies reveal striking differences between physiological and pathological angiogenesis potentially important for the development of tumor-specific, vascular-targeted therapies.
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