[HTML][HTML] G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts

KM D'Souza, R Malhotra, JL Philip, ML Staron… - Journal of Biological …, 2011 - ASBMB
Cardiac fibroblasts (CF) make up 60–70% of the total cell number in the heart and play a
critical role in regulating normal myocardial function and in adverse remodeling following
myocardial infarction and the transition to heart failure. Recent studies have shown that
increased intracellular cAMP can inhibit CF transformation and collagen synthesis in adult
rat CF; however, mechanisms by which cAMP production is regulated in CF have not been
elucidated. We investigated the potential role of G protein-coupled receptor kinase-2 (GRK2) …