Retained features of embryonic metabolism in the adult MRL mouse
RK Naviaux, TP Le, K Bedelbaeva, J Leferovich… - Molecular genetics and …, 2009 - Elsevier
The MRL mouse is an inbred laboratory strain that was derived by selective breeding in
1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of
other commonly used mouse strains, display uncommonly robust healing and regeneration
properties, and express later onset autoimmune traits similar to Systemic Lupus
Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14–20 quantitative
trait loci and the autoimmune traits map to 5–8 loci. In this paper we report the metabolic and …
1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of
other commonly used mouse strains, display uncommonly robust healing and regeneration
properties, and express later onset autoimmune traits similar to Systemic Lupus
Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14–20 quantitative
trait loci and the autoimmune traits map to 5–8 loci. In this paper we report the metabolic and …