Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation …
CJ Carter - Neurochemistry International, 2007 - Elsevier
Famine and viral infection, as well as interferon therapy have been reported to increase the
risk of developing bipolar disorder. In addition, almost 100 polymorphic genes have been
associated with this disease. Several form most of the components of a phosphatidyl-inositol
signalling/AKT1 survival pathway (PIK3C3, PIP5K2A, PLCG1, SYNJ1, IMPA2, AKT1,
GSK3B, TCF4) which is activated by growth factors (BDNF, NRG1) and also by NMDA
receptors (GRIN1, GRIN2A, GRIN2B). Various other protein products of genes associated …
risk of developing bipolar disorder. In addition, almost 100 polymorphic genes have been
associated with this disease. Several form most of the components of a phosphatidyl-inositol
signalling/AKT1 survival pathway (PIK3C3, PIP5K2A, PLCG1, SYNJ1, IMPA2, AKT1,
GSK3B, TCF4) which is activated by growth factors (BDNF, NRG1) and also by NMDA
receptors (GRIN1, GRIN2A, GRIN2B). Various other protein products of genes associated …