Predisposition to the development of IL-9–secreting T cells in atopic infants
W Yao, RS Tepper, MH Kaplan - Journal of allergy and clinical …, 2011 - jacionline.org
LETTERS TO THE EDITOR 1357 in mice results in allergic inflammation, antibodies to IL-9
block the development of allergic disease in mice, and polymorphisms in the IL9 and IL9R
genes are associated with atopic phenotypes in patients (reviewed in Goswami and Kaplan
1). Moreover, IL-9 is induced by allergen challenge in bronchoalveolar lavage lymphocytes
and by allergen stimulation of PBMCs isolated from atopic adults and preteens. 2-4 To
determine whether increased IL-9 production was an early indicator of allergic disease, we …
block the development of allergic disease in mice, and polymorphisms in the IL9 and IL9R
genes are associated with atopic phenotypes in patients (reviewed in Goswami and Kaplan
1). Moreover, IL-9 is induced by allergen challenge in bronchoalveolar lavage lymphocytes
and by allergen stimulation of PBMCs isolated from atopic adults and preteens. 2-4 To
determine whether increased IL-9 production was an early indicator of allergic disease, we …