Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

S Sanjabi, LA Zenewicz, M Kamanaka… - Current opinion in …, 2009 - Elsevier
Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state
and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead
to autoimmunity, whereas during inflammation they can cause excessive tissue damage.
Regulatory cytokines function in combination with other environmental signals to properly
modulate the function and the extent of lymphocyte activation. Many recent studies have
highlighted the importance of regulatory cytokines in controlling the differentiation and …