[HTML][HTML] The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
SM Srinivasula, JL Poyet, M Razmara, P Datta… - Journal of Biological …, 2002 - ASBMB
The PYRIN and CARD domains are members of the six-helix bundle death domain-fold
superfamily that mediates assembly of large signaling complexes in the apoptotic and
inflammatory signaling pathways. Here we show that the PYRIN-CARD protein ASC
functions as a caspase-1-activating adaptor. ASC interacted specifically with procaspase-1
via CARD-CARD interactions and induced its oligomerization. Consistent with these results
ectopic expression of full-length ASC, but not its isolated CARD or PYRIN domain, with …
superfamily that mediates assembly of large signaling complexes in the apoptotic and
inflammatory signaling pathways. Here we show that the PYRIN-CARD protein ASC
functions as a caspase-1-activating adaptor. ASC interacted specifically with procaspase-1
via CARD-CARD interactions and induced its oligomerization. Consistent with these results
ectopic expression of full-length ASC, but not its isolated CARD or PYRIN domain, with …