Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia
S Rosengren, JL Mueller, JP Anderson… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Familial cold autoinflammatory syndrome (FCAS) is characterized by rash,
fever, and arthralgia in response to cold exposure. CIAS1, the gene that codes for cryopyrin,
is mutated in FCAS. Treatment with anakinra (IL-1 receptor antagonist) prevents symptoms,
indicating a crucial role for IL-1 in this disease. OBJECTIVE: To study cytokine responses to
cold exposure in monocytes from subjects with FCAS. METHODS: Adherence-enriched
monocytes were incubated at 32° C or 37° C. Transcription and release of IL-1β, IL-6, and …
fever, and arthralgia in response to cold exposure. CIAS1, the gene that codes for cryopyrin,
is mutated in FCAS. Treatment with anakinra (IL-1 receptor antagonist) prevents symptoms,
indicating a crucial role for IL-1 in this disease. OBJECTIVE: To study cytokine responses to
cold exposure in monocytes from subjects with FCAS. METHODS: Adherence-enriched
monocytes were incubated at 32° C or 37° C. Transcription and release of IL-1β, IL-6, and …