Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis
J Ostermann, AL Horwich, W Neupert, FU Hartl - Nature, 1989 - nature.com
J Ostermann, AL Horwich, W Neupert, FU Hartl
Nature, 1989•nature.comProtein folding in mitochondria requires Page 1 ARTICLES Protein folding in mitochondria
requires complex formation with hsp60 and ATP hydrolysis Joachim Ostermann, Arthur L. Horwich,
Walter Neupert & F-Ulrich Hartl Institut für Physiologische Chemie der Universität München,
Goethestrasse 33, 8000 München 2, FRG *Yale University School of Medicine, Department of
Human Genetics, 333 Cedar Street, New Haven, Connecticut O6510, USA Mitochondrial
heat-shock protein hsp6O functions in the folding of proteins imported into mitochondria …
requires complex formation with hsp60 and ATP hydrolysis Joachim Ostermann, Arthur L. Horwich,
Walter Neupert & F-Ulrich Hartl Institut für Physiologische Chemie der Universität München,
Goethestrasse 33, 8000 München 2, FRG *Yale University School of Medicine, Department of
Human Genetics, 333 Cedar Street, New Haven, Connecticut O6510, USA Mitochondrial
heat-shock protein hsp6O functions in the folding of proteins imported into mitochondria …
Abstract
Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochon-dria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.
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