AG protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide
H Jüppner, AB Abou-Samra, M Freeman, XF Kong… - Science, 1991 - science.org
Science, 1991•science.org
The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid
hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning
domains was cloned by COS-7 expression using an opossum kidney cell complementary
DNA (cDNA) library. The expressed receptor binds PTH and PTHrP with equal affinity, and
both ligands equivalently stimulate adenylate cyclase. Striking homology with the calcitonin
receptor and lack of homology with other G protein-linked receptors indicate that receptors …
hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning
domains was cloned by COS-7 expression using an opossum kidney cell complementary
DNA (cDNA) library. The expressed receptor binds PTH and PTHrP with equal affinity, and
both ligands equivalently stimulate adenylate cyclase. Striking homology with the calcitonin
receptor and lack of homology with other G protein-linked receptors indicate that receptors …
The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library. The expressed receptor binds PTH and PTHrP with equal affinity, and both ligands equivalently stimulate adenylate cyclase. Striking homology with the calcitonin receptor and lack of homology with other G protein-linked receptors indicate that receptors for these calcium-regulating hormones are related and represent a new family.
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