Antipsychotic drugs and QT prolongation

C Stöllberger, JO Huber, J Finsterer - International clinical …, 2005 - journals.lww.com
Antipsychotic drugs (AD) are effective and frequently prescribed to more females than
males. AD may cause serious cardiovascular side-effects, including prolonged QT interval,
eventually leading to torsades de pointes (TdP) and sudden death. Epidemiologic data and
case–control studies indicate an increased rate of sudden death in psychiatric patients
taking AD. This review summarizes current knowledge about the QT prolonging effects of AD
and gives practical suggestions. Amisulpride, clozapine, flupenthixol, fluphenazine …