[HTML][HTML] Common genetic influences for schizophrenia and bipolar disorder: A population-based study of 2 million nuclear families
Lancet, 2009•ncbi.nlm.nih.gov
Background A persistent debate in psychiatry concerns whether schizophrenia and bipolar
disorder are the clinical realizations of discrete versus shared etiological processes.
Methods We linked the Multi-Generation Register, containing information about children and
their parents of all Swedes, and the Hospital Discharge Register, covering all public
psychiatric inpatient hospitalizations in Sweden. We identified 9,009,202 unique individuals
in more than 2 million nuclear families. Risks for schizophrenia, bipolar disorder and their co …
disorder are the clinical realizations of discrete versus shared etiological processes.
Methods We linked the Multi-Generation Register, containing information about children and
their parents of all Swedes, and the Hospital Discharge Register, covering all public
psychiatric inpatient hospitalizations in Sweden. We identified 9,009,202 unique individuals
in more than 2 million nuclear families. Risks for schizophrenia, bipolar disorder and their co …
Abstract
Background
A persistent debate in psychiatry concerns whether schizophrenia and bipolar disorder are the clinical realizations of discrete versus shared etiological processes.
Methods
We linked the Multi-Generation Register, containing information about children and their parents of all Swedes, and the Hospital Discharge Register, covering all public psychiatric inpatient hospitalizations in Sweden. We identified 9,009,202 unique individuals in more than 2 million nuclear families. Risks for schizophrenia, bipolar disorder and their co-morbidity were calculated for biological and adoptive parents, offspring, full siblings and half-siblings of probands with the diseases. A multivariate generalized linear mixed model was used to estimate genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and their co-morbidity.
ncbi.nlm.nih.gov