Objective To collect the information necessary to design the methods and outcome variables
for a larger trial of scheduled deep brain stimulation (DBS) for Tourette syndrome. Design
We performed a small National Institutes of Health–sponsored clinical trials planning study
of the safety and preliminary efficacy of implanted DBS in the bilateral centromedian
thalamic region. The study used a cranially contained constant-current device and a
scheduled, rather than the classic continuous, DBS paradigm. Baseline vs 6-month …