A tractography analysis of two deep brain stimulation white matter targets for depression
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate white matter
(SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating
depression. Connectivity patterns of these regions may inform on mechanisms of action for
DBS of these targets. METHODS: Diffusion tensor imaging (DTI) and FSL-based
probabilistic tractography were performed in 13 nondepressed subjects to determine
connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in …
(SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating
depression. Connectivity patterns of these regions may inform on mechanisms of action for
DBS of these targets. METHODS: Diffusion tensor imaging (DTI) and FSL-based
probabilistic tractography were performed in 13 nondepressed subjects to determine
connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in …