BACKGROUND: Functional neuroimaging studies have provided consistent support for the
idea that obsessive-compulsive disorder (OCD) is associated with disturbances of brain
corticostriatal systems. However, in general, these studies have not sought to account for the
disorder's prominent clinical heterogeneity. METHODS: To address these concerns, we
investigated the influence of major OCD symptom dimensions on brain corticostriatal
functional systems in a large sample of OCD patients (n= 74) and control participants (n= 74) …