[HTML][HTML] Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor

H Azriel-Tamir, H Sharir, B Schwartz… - Journal of Biological …, 2004 - ASBMB
Extracellular zinc promotes cell proliferation and its deficiency leads to impairment of this
process, which is particularly important in epithelial cells. We have recently characterized a
zinc-sensing receptor (ZnR) linking extracellular zinc to intracellular release of calcium. In
the present study, we addressed the role of extracellular zinc, acting via the ZnR, in
regulating the MAP kinase pathway and Na+/H+ exchange in colonocytes. We demonstrate
that Ca 2+ release, mediated by the ZnR, induces phosphorylation of ERK1/2, which is …