Decrease of CD4+ CD25highFoxp3+ regulatory T cells and elevation of CD19+ BAFF-R+ B cells and soluble ICAM-1 in myasthenia gravis
X Li, BG Xiao, JY Xi, CZ Lu, JH Lu - Clinical immunology, 2008 - Elsevier
Myasthenia gravis (MG) is caused by T-cell-dependent autoantibodies against muscle
acetylcholine receptors (AChR) at the neuromuscular junction. Here, we adopted ELISA and
flow cytometry techniques to measure the levels of Th1, Th2, Th3 cytokines, inflammatory
cytokine and chemokine sICAM-1 and to analyze the phenotypes of CD4+ and CD8+
regulatory cells as well as the expression of BAFF-R on CD19+ B cells in peripheral blood
from 75 MG patients and 50 healthy controls. There were no differences in the levels of IL-2 …
acetylcholine receptors (AChR) at the neuromuscular junction. Here, we adopted ELISA and
flow cytometry techniques to measure the levels of Th1, Th2, Th3 cytokines, inflammatory
cytokine and chemokine sICAM-1 and to analyze the phenotypes of CD4+ and CD8+
regulatory cells as well as the expression of BAFF-R on CD19+ B cells in peripheral blood
from 75 MG patients and 50 healthy controls. There were no differences in the levels of IL-2 …