[HTML][HTML] cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid …
DM Erion, ME Kotas, J McGlashon, S Yonemitsu… - Journal of Biological …, 2013 - ASBMB
cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2
(CRTC2) regulates transcription of gluconeogenic genes by specifying targets for the
transcription factor CREB in response to glucagon. We used an antisense oligonucleotide
directed against CRTC2 in both normal rodents and in rodent models of increased
gluconeogenesis to better understand the role of CRTC2 in metabolic disease. In the context
of severe hyperglycemia and elevated hepatic glucose production, CTRC2 knockdown (KD) …
(CRTC2) regulates transcription of gluconeogenic genes by specifying targets for the
transcription factor CREB in response to glucagon. We used an antisense oligonucleotide
directed against CRTC2 in both normal rodents and in rodent models of increased
gluconeogenesis to better understand the role of CRTC2 in metabolic disease. In the context
of severe hyperglycemia and elevated hepatic glucose production, CTRC2 knockdown (KD) …