[HTML][HTML] Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
T Hershko, D Ginsberg - Journal of Biological Chemistry, 2004 - ASBMB
The E2F1 transcription factor is a critical downstream target of the tumor suppressor pRB.
The retinoblastoma (RB) pathway is often inactivated in human tumors, resulting in
deregulated E2F activity that can induce both proliferation and apoptosis. Bcl-2 homology 3
(BH3)-only proteins are pro-apoptotic members of the Bcl-2 protein family that trigger
apoptosis in response to diverse stimuli. We show here that E2F1 up-regulates the
expression of the pro-apoptotic BH3-only proteins PUMA, Noxa, Bim, and Hrk/DP5 through a …
The retinoblastoma (RB) pathway is often inactivated in human tumors, resulting in
deregulated E2F activity that can induce both proliferation and apoptosis. Bcl-2 homology 3
(BH3)-only proteins are pro-apoptotic members of the Bcl-2 protein family that trigger
apoptosis in response to diverse stimuli. We show here that E2F1 up-regulates the
expression of the pro-apoptotic BH3-only proteins PUMA, Noxa, Bim, and Hrk/DP5 through a …