Rho GTPases and regulation of hematopoietic stem cell localization

DA Williams, Y Zheng, JA Cancelas - Methods in enzymology, 2008 - Elsevier
Bone marrow engraftment in the context of hematopoietic stem cell and progenitor (HSC/P)
transplantation is based on the ability of intravenously administered cells to lodge in the
medullary cavity and be retained in the appropriate marrow space, a process referred to as
homing. It is likely that homing is a multistep process, encompassing a sequence of highly
regulated events that mimic the migration of leukocytes to inflammatory sites. In leukocyte
biology, this process includes an initial phase of tethering and rolling of cells to the …