[HTML][HTML] Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis
Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 12-acetate (TPA)
enables radiation-resistant LNCaP human prostate cancer cells to undergo radiation-
induced apoptosis, mediated via activation of the enzyme ceramide synthase (CS) and de
novo synthesis of the sphingolipid ceramide (Garzotto, M., Haimovitz-Friedman, A., Liao,
WC, White-Jones, M., Huryk, R., Heston, DWW, Cardon-Cardo, C., Kolesnick, R., and Fuks,
Z.(1999) Cancer Res. 59, 5194–5201). Here, we show that TPA functions to decrease the …
enables radiation-resistant LNCaP human prostate cancer cells to undergo radiation-
induced apoptosis, mediated via activation of the enzyme ceramide synthase (CS) and de
novo synthesis of the sphingolipid ceramide (Garzotto, M., Haimovitz-Friedman, A., Liao,
WC, White-Jones, M., Huryk, R., Heston, DWW, Cardon-Cardo, C., Kolesnick, R., and Fuks,
Z.(1999) Cancer Res. 59, 5194–5201). Here, we show that TPA functions to decrease the …