[HTML][HTML] Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain …
A Millon-Frémillon, M Brunner, N Abed… - Journal of Biological …, 2013 - ASBMB
Focal adhesion turnover during cell migration is an integrated cyclic process requiring tight
regulation of integrin function. Interaction of integrin with its ligand depends on its activation
state, which is regulated by the direct recruitment of proteins onto the β integrin chain
cytoplasmic domain. We previously reported that ICAP-1α, a specific cytoplasmic partner of
β1A integrins, limits both talin and kindlin interaction with β1 integrin, thereby restraining
focal adhesion assembly. Here we provide evidence that the calcium and calmodulin …
regulation of integrin function. Interaction of integrin with its ligand depends on its activation
state, which is regulated by the direct recruitment of proteins onto the β integrin chain
cytoplasmic domain. We previously reported that ICAP-1α, a specific cytoplasmic partner of
β1A integrins, limits both talin and kindlin interaction with β1 integrin, thereby restraining
focal adhesion assembly. Here we provide evidence that the calcium and calmodulin …