New insights into the role of NK cells in cancer immunotherapy

M Salagianni, CN Baxevanis, M Papamichail… - …, 2012 - Taylor & Francis
M Salagianni, CN Baxevanis, M Papamichail, SA Perez
Oncoimmunology, 2012Taylor & Francis
Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a
metastatic lung cancer mouse model. These were further potentiated by Treg depletion.
Thus the combination of NK cell-based immunotherapy with other treatment modalities in the
direction of adaptive response enhancement might promote long lasting antitumor immunity.
Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity.
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