This is the first in a series of review articles describing the current state of research on
mouse lung tumorigenesis. The system is valuable as a biological model for studying stages
of tumor development and the interaction of genetic and environmental factors which
dispose towards neoplasia. Additionally, these tumors are analagous to bronchiolo-alveolar
cancer in man. Three pulmonary adenoma susceptibility (Pas) genes regulate susceptibility;
1 of these is the proto-oncogene, K-ras 2. Candidates for the other 2 genes include the H-2 …