Kidney dendritic cells become pathogenic during crescentic glomerulonephritis with proteinuria
It is unclear why kidney dendritic cells attenuate some models of kidney disease but
aggravate others. Kidney dendritic cells ameliorate the early phase of nonaccelerated
nephrotoxic nephritis, a murine model of crescentic glomerulonephritis, but their effect on the
later phase is unknown. Here, we report that kidney dendritic cells at later stages of
nephrotoxic nephritis expressed higher levels of costimulatory molecules but lower levels of
the cosuppressor molecule ICOS-L and started production of IL-12/23p40 and TNF-α …
aggravate others. Kidney dendritic cells ameliorate the early phase of nonaccelerated
nephrotoxic nephritis, a murine model of crescentic glomerulonephritis, but their effect on the
later phase is unknown. Here, we report that kidney dendritic cells at later stages of
nephrotoxic nephritis expressed higher levels of costimulatory molecules but lower levels of
the cosuppressor molecule ICOS-L and started production of IL-12/23p40 and TNF-α …