[HTML][HTML] Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways
JL Slack, K Schooley, TP Bonnert, JL Mitcham… - Journal of Biological …, 2000 - ASBMB
Type I interleukin-1 receptor is the prototype for a family of proteins, which play a central role
in early responses to injury and infection. The similarity of function across the family is
reflected in similarity in signaling: all members tested couple to activation of NFκB and stress
kinases. The coupling to these pathways is mediated by a 200-residue intracellular domain
(the Toll/interleukin-1 receptor domain), in which sequence conservation is primarily
confined to three short motifs (boxes 1, 2, and 3) located at amino acid residue positions 10 …
in early responses to injury and infection. The similarity of function across the family is
reflected in similarity in signaling: all members tested couple to activation of NFκB and stress
kinases. The coupling to these pathways is mediated by a 200-residue intracellular domain
(the Toll/interleukin-1 receptor domain), in which sequence conservation is primarily
confined to three short motifs (boxes 1, 2, and 3) located at amino acid residue positions 10 …