Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
Immunology today, 2000•cell.com
Natural killer (NK) cells can detect whether cells have undergone tumour transformation or
viral infection. The discovery of specific inhibitory receptors for major histocompatibility
complex class I molecules clarified the basis of this discrimination. However, the receptors
responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until
recently. Here, Alessandro Moretta and colleagues describe the identification and
characterization of several such receptors.
viral infection. The discovery of specific inhibitory receptors for major histocompatibility
complex class I molecules clarified the basis of this discrimination. However, the receptors
responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until
recently. Here, Alessandro Moretta and colleagues describe the identification and
characterization of several such receptors.
Abstract
Natural killer (NK) cells can detect whether cells have undergone tumour transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.
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