Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation
SW Biggins, J Trotter, J Gralla, JR Burton Jr… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: IL28B single nucleotide polymorphisms are strongly associated
with spontaneous HCV clearance and treatment response in non-transplant populations. A
DDX58 single nucleotide polymorphism is associated with the antiviral response of innate
lymphocytes. We aimed at evaluating the associations of donor and recipient IL28B
(rs12979860 and rs8099917) and DDX58 (rs10813831) genotypes with severity of HCV
recurrence after liver transplantation. METHODS: In a case-control study of 523 liver …
with spontaneous HCV clearance and treatment response in non-transplant populations. A
DDX58 single nucleotide polymorphism is associated with the antiviral response of innate
lymphocytes. We aimed at evaluating the associations of donor and recipient IL28B
(rs12979860 and rs8099917) and DDX58 (rs10813831) genotypes with severity of HCV
recurrence after liver transplantation. METHODS: In a case-control study of 523 liver …