[HTML][HTML] Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet
fully understood. Previous chimpanzee and now human studies suggest that mutations
within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T
lymphocyte (CTL) responses. However, there are several outstanding questions regarding
the role of escape mutations in viral persistence and their fate in the absence of immune
selection pressure.
fully understood. Previous chimpanzee and now human studies suggest that mutations
within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T
lymphocyte (CTL) responses. However, there are several outstanding questions regarding
the role of escape mutations in viral persistence and their fate in the absence of immune
selection pressure.
Abstract
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.
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