Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice
K Lacek, K Vercauteren, K Grzyb, M Naddeo… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Hepatitis C virus (HCV)-induced end-stage liver disease is
currently the major indication for liver transplantation in the Western world. After
transplantation, the donor liver almost inevitably becomes infected by the circulating virus
and disease progression is accelerated in immune suppressed transplant patients. The
current standard therapy, based on pegylated interferon and ribavirin, induces severe side
effects and is often ineffective in this population. Therefore, new strategies to prevent graft re …
currently the major indication for liver transplantation in the Western world. After
transplantation, the donor liver almost inevitably becomes infected by the circulating virus
and disease progression is accelerated in immune suppressed transplant patients. The
current standard therapy, based on pegylated interferon and ribavirin, induces severe side
effects and is often ineffective in this population. Therefore, new strategies to prevent graft re …