The C‐terminus of tissue factor pathway inhibitor α is required for its interaction with factors V and Va
M Ndonwi, TJ Girard, GJ Broze - Journal of Thrombosis and …, 2012 - jthjournal.org
Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitztype protease inhibitor that
regulates tissue factor (TF)-induced coagulation by inhibiting factor Xa and the FVIIa–TF
complex [1]. Full-length TFPIo (FL-TFPIo) is a 276-residue glycoprotein with an acidic N-
terminus followed by three tandem Kunitztype domains and a basic C-terminus. In humans,
80% of circulating TFPI is tightly bound to plasma lipoproteins (LDL> HDL> VLDL), and
lacks the third Kunitz domain (K3) and C-terminus of TFPIo [2]. The remaining TFPI consists …
regulates tissue factor (TF)-induced coagulation by inhibiting factor Xa and the FVIIa–TF
complex [1]. Full-length TFPIo (FL-TFPIo) is a 276-residue glycoprotein with an acidic N-
terminus followed by three tandem Kunitztype domains and a basic C-terminus. In humans,
80% of circulating TFPI is tightly bound to plasma lipoproteins (LDL> HDL> VLDL), and
lacks the third Kunitz domain (K3) and C-terminus of TFPIo [2]. The remaining TFPI consists …