[HTML][HTML] A model for the stoichiometric regulation of blood coagulation
MF Hockin, KC Jones, SJ Everse, KG Mann - Journal of Biological …, 2002 - ASBMB
We have developed a model of the extrinsic blood coagulation system that includes the
stoichiometric anticoagulants. The model accounts for the formation, expression, and
propagation of the vitamin K-dependent procoagulant complexes and extends our previous
model by including:(a) the tissue factor pathway inhibitor (TFPI)-mediated inactivation of
tissue factor (TF)· VIIa and its product complexes;(b) the antithrombin-III (AT-III)-mediated
inactivation of IIa, mIIa, factor VIIa, factor IXa, and factor Xa;(c) the initial activation of factor V …
stoichiometric anticoagulants. The model accounts for the formation, expression, and
propagation of the vitamin K-dependent procoagulant complexes and extends our previous
model by including:(a) the tissue factor pathway inhibitor (TFPI)-mediated inactivation of
tissue factor (TF)· VIIa and its product complexes;(b) the antithrombin-III (AT-III)-mediated
inactivation of IIa, mIIa, factor VIIa, factor IXa, and factor Xa;(c) the initial activation of factor V …